We invite you to discover Human Gene Therapy Clinical Development, a peer-reviewed journal publishing preclinical research and clinical trial data for gene and cell therapies.

Publication 12/10/2014

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna.

Hinderer C, Bell P, Vite CH, Louboutin JP, Grant R, Bote E, Yu H, Pukenas B, Hurst R, Wilson JM

Molecular Therapy. Methods & Clinical Development

Publication 12/01/2014

Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 11/13/2014

Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression.

Greig JA, Peng H, Ohlstein J, Medina-Jaszek CA, Ahonkhai O, Mentzinger A, Grant RL, Roy S, Chen SJ, Bell P, Tretiakova AP, Wilson JM

Plos One

Publication 11/01/2014

In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection.

Myint M, Limberis MP, Bell P, Somanathan S, Haczku A, Wilson JM, Diamond SL

Human Gene Therapy

Publication 11/01/2014

Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus.

Adam VS, Crosariol M, Kumar S, Ge MQ, Czack SE, Roy S, Haczku A, Tretiakova A, Wilson JM, Limberis MP

Clinical And Vaccine Immunology : Cvi

Publication 10/14/2014

Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM

Proceedings Of The National Academy Of Sciences Of The United States Of America