We invite you to discover Human Gene Therapy Clinical Development, a peer-reviewed journal publishing preclinical research and clinical trial data for gene and cell therapies.

Publication 12/01/2009

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM

Gene Therapy

Publication 12/01/2009

A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque.

Lin J, Calcedo R, Vandenberghe LH, Bell P, Somanathan S, Wilson JM

Journal Of Virology

Publication 9/01/2009

Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.

Gao G, Wang Q, Calcedo R, Mays L, Bell P, Wang L, Vandenberghe LH, Grant R, Sanmiguel J, Furth EE, Wilson JM

Human Gene Therapy

Publication 8/01/2009

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

Breous E, Somanathan S, Vandenberghe LH, Wilson JM

Hepatology

Publication 7/01/2009

Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates.

Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM

Plos Pathogens

Publication 5/15/2009

Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins.

Mays LE, Vandenberghe LH, Xiao R, Bell P, Nam HJ, Agbandje-McKenna M, Wilson JM

Journal Of Immunology