Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.
Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM
A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque.
Lin J, Calcedo R, Vandenberghe LH, Bell P, Somanathan S, Wilson JM
Journal Of Virology
Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.
Gao G, Wang Q, Calcedo R, Mays L, Bell P, Wang L, Vandenberghe LH, Grant R, Sanmiguel J, Furth EE, Wilson JM
Human Gene Therapy
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.
Breous E, Somanathan S, Vandenberghe LH, Wilson JM
Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates.
Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins.
Mays LE, Vandenberghe LH, Xiao R, Bell P, Nam HJ, Agbandje-McKenna M, Wilson JM
Journal Of Immunology