We invite you to discover Human Gene Therapy Clinical Development, a peer-reviewed journal publishing preclinical research and clinical trial data for gene and cell therapies.

Publication 12/01/2009

A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque.

Lin J, Calcedo R, Vandenberghe LH, Bell P, Somanathan S, Wilson JM

Journal Of Virology

Publication 9/22/2009

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.

Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR

Proceedings Of The National Academy Of Sciences Of The United States Of America

Publication 9/01/2009

Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.

Gao G, Wang Q, Calcedo R, Mays L, Bell P, Wang L, Vandenberghe LH, Grant R, Sanmiguel J, Furth EE, Wilson JM

Human Gene Therapy

Publication 7/01/2009

Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates.

Roy S, Vandenberghe LH, Kryazhimskiy S, Grant R, Calcedo R, Yuan X, Keough M, Sandhu A, Wang Q, Medina-Jaszek CA, Plotkin JB, Wilson JM

Plos Pathogens

Publication 3/01/2009

Host immune responses to chronic adenovirus infections in human and nonhuman primates.

Calcedo R, Vandenberghe LH, Roy S, Somanathan S, Wang L, Wilson JM

Journal Of Virology

Publication 2/01/2009

Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses.

Calcedo R, Vandenberghe LH, Gao G, Lin J, Wilson JM

The Journal Of Infectious Diseases