AAV9 targets cone photoreceptors in the nonhuman primate retina.
Vandenberghe LH, Bell P, Maguire AM, Xiao R, Hopkins TB, Grant R, Bennett J, Wilson JM
Influence of serotype, cell type, tissue composition, and time after inoculation on gene expression in recombinant adeno-associated viral vector-transduced equine joint tissues.
Mason JB, Vandenberghe LH, Xiao R, Wilson JM, Richardson DW
American Journal Of Veterinary Research
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.
Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J
Science Translational Medicine
Efficient serotype-dependent release of functional vector into the culture medium during adeno-associated virus manufacturing.
Vandenberghe LH, Xiao R, Lock M, Lin J, Korn M, Wilson JM
Human Gene Therapy
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.
Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins.
Mays LE, Vandenberghe LH, Xiao R, Bell P, Nam HJ, Agbandje-McKenna M, Wilson JM
Journal Of Immunology