We invite you to discover Human Gene Therapy Clinical Development, a peer-reviewed journal publishing preclinical research and clinical trial data for gene and cell therapies.

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Publication 1/01/2010

Systematic evaluation of AAV vectors for liver directed gene transfer in murine models.

Wang L, Wang H, Bell P, McCarter RJ, He J, Calcedo R, Vandenberghe LH, Morizono H, Batshaw ML, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 1/01/2010

The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques.

Wang L, Calcedo R, Wang H, Bell P, Grant R, Vandenberghe LH, Sanmiguel J, Morizono H, Batshaw ML, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 9/22/2009

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy.

Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR

Proceedings Of The National Academy Of Sciences Of The United States Of America

Publication 9/01/2009

Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.

Gao G, Wang Q, Calcedo R, Mays L, Bell P, Wang L, Vandenberghe LH, Grant R, Sanmiguel J, Furth EE, Wilson JM

Human Gene Therapy

Publication 3/01/2009

Host immune responses to chronic adenovirus infections in human and nonhuman primates.

Calcedo R, Vandenberghe LH, Roy S, Somanathan S, Wang L, Wilson JM

Journal Of Virology

Publication 3/01/2007

Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets.

Wang L, Figueredo J, Calcedo R, Lin J, Wilson JM

Human Gene Therapy