Publication
3/01/2017
Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia.
Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM
Human Gene Therapy. Clinical Development
Publication
3/01/2017
Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR+/- Rhesus Macaques.
Greig JA, Limberis MP, Bell P, Chen SJ, Calcedo R, Rader DJ, Wilson JM
Human Gene Therapy Clinical Development
Publication
5/01/2016
Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol.
Ibrahim S, Somanathan S, Billheimer J, Wilson JM, Rader DJ
Cardiovascular Research
Publication
8/29/2014
AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia.
Somanathan S, Jacobs F, Wang Q, Hanlon AL, Wilson JM, Rader DJ
Circulation Research
Publication
12/01/2013
Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia.
Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis MP, Kassim SH, Somanathan S, Bell P, Johnston JC, Rader DJ, Wilson JM
Human Gene Therapy. Clinical Development
Publication
1/01/2013
Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.
Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ
Human Gene Therapy