Publication 1/01/2014

AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.

Mays LE, Wang L, Lin J, Bell P, Crawford A, Wherry EJ, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 9/01/2013

Mapping the structural determinants responsible for enhanced T cell activation to the immunogenic adeno-associated virus capsid from isolate rhesus 32.33.

Mays LE, Wang L, Tenney R, Bell P, Nam HJ, Lin J, Gurda B, Van Vliet K, Mikals K, Agbandje-McKenna M, Wilson JM

Journal Of Virology

Publication 4/01/2012

Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.

Wang L, Wang H, Morizono H, Bell P, Jones D, Lin J, McMenamin D, Yu H, Batshaw ML, Wilson JM

Gene Therapy

Publication 2/01/2012

Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.

Wang L, Morizono H, Lin J, Bell P, Jones D, McMenamin D, Yu H, Batshaw ML, Wilson JM

Molecular Genetics And Metabolism

Publication 11/01/2011

Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors.

Wang L, Calcedo R, Bell P, Lin J, Grant RL, Siegel DL, Wilson JM

Human Gene Therapy

Publication 11/01/2011

AAV8-mediated hepatic gene transfer in infant rhesus monkeys (Macaca mulatta).

Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy