Publication 12/01/2013

Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia.

Chen SJ, Sanmiguel J, Lock M, McMenamin D, Draper C, Limberis MP, Kassim SH, Somanathan S, Bell P, Johnston JC, Rader DJ, Wilson JM

Human Gene Therapy. Clinical Development

Publication 1/01/2013

Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.

Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ

Human Gene Therapy

Publication 8/16/2011

Identification and functional characterization in vivo of a novel splice variant of LDLR in rhesus macaques.

Kassim SH, Vandenberghe LH, Hovhannisyan R, Wilson JM, Rader DJ

Physiological Genomics

Publication 10/19/2010

Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.

Kassim SH, Li H, Vandenberghe LH, Hinderer C, Bell P, Marchadier D, Wilson A, Cromley D, Redon V, Yu H, Wilson JM, Rader DJ

Plos One

Publication 6/01/2010

Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies.

Kassim SH, Wilson JM, Rader DJ

Clinical Lipidology