Publication 7/01/2011

Inflammation promotes the loss of adeno-associated virus-mediated transgene expression in mouse liver.

Breous E, Somanathan S, Bell P, Wilson JM

Gastroenterology

Publication 5/01/2010

AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells.

Somanathan S, Breous E, Bell P, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 4/01/2010

BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver.

Breous E, Somanathan S, Wilson JM

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 12/01/2009

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM

Gene Therapy

Publication 11/01/2009

Identification of the immunodominant cytotoxic T-cell epitope of human alpha-1 antitrypsin.

Breous E, Somanathan S, Wilson JM

Gene Therapy

Publication 8/01/2009

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

Breous E, Somanathan S, Vandenberghe LH, Wilson JM

Hepatology