We invite you to discover Human Gene Therapy Clinical Development, a peer-reviewed journal publishing preclinical research and clinical trial data for gene and cell therapies.

Publication 2/15/2004

Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.

Choi EA, Lei H, Maron DJ, Mick R, Barsoum J, Yu QC, Fraker DL, Wilson JM, Spitz FR

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Publication 9/01/2003

Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells.

Choi EA, Lei H, Maron DJ, Wilson JM, Barsoum J, Fraker DL, El-Deiry WS, Spitz FR

Cancer Research

Publication 8/15/2001

Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity.

Odaka M, Sterman DH, Wiewrodt R, Zhang Y, Kiefer M, Amin KM, Gao GP, Wilson JM, Barsoum J, Kaiser LR, Albelda SM

Cancer Research

Publication 7/01/2001

Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.

Tada H, Maron DJ, Choi EA, Barsoum J, Lei H, Xie Q, Liu W, Ellis L, Moscioni AD, Tazelaar J, Fawell S, Qin X, Propert KJ, Davis A, Fraker DL, Wilson JM, Spitz FR

The Journal Of Clinical Investigation

Publication 1/01/2001

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver.

Tao N, Gao GP, Parr M, Johnston J, Baradet T, Wilson JM, Barsoum J, Fawell SE

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Publication 11/24/1998

Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.

Qin XQ, Tao N, Dergay A, Moy P, Fawell S, Davis A, Wilson JM, Barsoum J

Proceedings Of The National Academy Of Sciences Of The United States Of America