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There are 500,000 influenza-related deaths annually worldwide. In addition to seasonal influenza, new strains of influenza have the potential to cause a global pandemic. Vaccines are not always effective at protecting humans from influenza, and may not be available during a pandemic. In collaboration with Janssen Pharmaceuticals, Inc., GTP is developing AAV-based prophylactics against influenza A and B as an alternative to the traditional influenza vaccine in the setting of seasonal and/or pandemic influenza infections.