Repurposing a proven gene therapy approach to treat, prevent COVID-19

In a Q&A, Penn Medicine’s James M. Wilson discusses using adeno-associated viral vectors to transport a lab-made antibody cocktail into the body. This method, delivered via nasal spray or mist, has the potential to act as a ‘bioshield’ against SARS-CoV-2.


Penn Medicine Collaborates with Regeneron to Investigate Delivery of COVID-19 Antibody Cocktail via Gene Therapy Platform

Gene Therapy Pioneer James Wilson leading studies of adeno-associated viral vectors to potentially prevent COVID-19


Penn Researchers Develop Approach to Prevent Toxicity Tied to Neurological Gene Therapy

Penn Medicine researchers have developed a new targeted approach to prevent a toxicity seen in the sensory neurons of dorsal root ganglia after gene therapy to treat neurological disorders. It’s an important hurdle to clear, as the field works toward more safe and effective gene therapies for patients with disorders like spinal muscular atrophy.


Philadelphia is poised to become the epicenter of cell and gene therapy

THE 7,600-JOB MOMENT Philadelphia is poised to become the epicenter of cell and gene therapy. Leaders like Dr. Steven Nichtberger have brought the local industry to a ‘tipping point.’


A quest for Quincy: Gene therapies come of age for some forms of autism

Allyson Berent is a specialty veterinarian in New York City. She treats animals that other doctors cannot help. When no good therapies are available, she invents one. Cats and dogs consumed almost all of her time — until six years ago, when her second daughter was born.


The Wilderness of Rare Genetic Diseases and the Parents Navigating It

“Rare parents” are often left charting a world of unknowns. But their persistence has paid off with more advanced treatment options.