iPSC Core

Human inducible pluripotent stem cells (hiPSC) play an emerging role for individualized medicine and drug screening. The iPSC Resource Center utilizes human iPSCs in combination with directed differentiation to model genetically defined diseases, and uses this platform to screen viral vectors for gene therapy.

stemcells

Differentiation of Human iPSCs

This technique reprograms adult cells to make them pluripotent, meaning that they are then capable of transforming into any type of cell in the body.  This technology has many applications in science and medicine. In addition to stem cell therapy, iPSCs can be used to develop disease models that can be used to screen and develop new drugs and therapies in the laboratory.   

Services Performed

  • Generation of hiPSC from somatic cells (skin fibroblast cells, PBMCs)
  • Maintainence of hiPSC
  • Direct differentiation of hiPSC
    • Hepatocyte-like Cell
    • Pancreatic β-like cell
    • Motor Neuron
    • Medium Spiny Neuron/GABAergic Inhibitory Neuron
    • Dorsal Root Ganglion
  • Genome Editing of hiPSCs
  • Viral Vector Transduction Testing
  • Teaching and Training on Stem Cell-Relevant Techniques
  • High-throughput drug screening, especially for motor neurons